Brampton Fire said the blaze was put under control around 5 a.m.
Peel Regional Police say a woman was pulled out of the home but died at the scene. A man suffered burns and smoke inhalation and was taken to hospital.
Another man was arrested nearby, cops said.
The homicide unit and the Office of the Fire Marshal will investigate the incident.
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Postmedia is committed to maintaining a lively but civil forum for discussion. Please keep comments relevant and respectful. Comments may take up to an hour to appear on the site. You will receive an email if there is a reply to your comment, an update to a thread you follow or if a user you follow comments. Visit our Community Guidelines for more information.