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PRIME TIME PICK: Niners running back injuries catch up to them against Rams

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LOS ANGELES RAMS (7-6) at SAN FRANCISCO 49ers (6-7)

LINE: San Francisco by 2.5

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It looks like the Niners will be down to their fourth-string running back with Isaac Guerendo (foot) expected to join Christian McCaffrey and Jordan Mason on the sidelines. Patrick Taylor might have a chance of having success against the Rams’ 28th-ranked run defence if tackle Trent Williams was returning, but it appears neither he nor Nick Bosa will be back for this one. The Rams scored 44 points against the Buffalo Bills last week while the Niners crushed a much weaker opponent in the Chicago Bears. L.A. beat San Fran 27-24 in Week 3 without Puka Nacua and Cooper Kupp.

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TAKING: L.A. RAMS +2.5

Score: Rams 24, Niners 23

Dan Bilicki: San Francisco -2.5

Dan Bilicki

LAST WEEK: 9-4

SEASON: 107–99-2

BEST BEST LAST WEEK: 1-0

BEST BET SEASON: 7-7

Don Brennan

LAST WEEK: 4-9

SEASON: 101-105-2

BEST BETS LAST WEEK: 1-2

BEST BET SEASON: 22–19-1

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